Table 4. Antecedent Change in Composite PROMIS SPADE T Score as a Predictor of Subsequent Functional Status Outcomes over 12 Months^*.

Functional Status Outcome	Beta coefficient (SE)	P-value	Change in outcome per 5-point improvement in PROMIS composite score	Effect size†
Mental component summary score (MCS), SF-12	0.586 (.060)	<.0001	2.9 point increased (improved) score	0.24
Social functioning, SF-36	1.200 (.151)	<.0001	6.0 point increased (improved) score	0.22
Health-related disability days in past 4 weeks	-0.302 (.053)	<.0001	1.51 less disability days in past 4 weeks	0.18
Physical component summary score (PCS), SF-12	0.172 (.053)	.0014	0.9 point increased (improved) score	0.10
General health item, SF-12	0.534 (.148)	.0004	2.7 point increased (improved) score	0.09
Percent work effectiveness	0.318 (.182)	.083	1.6% increased (improved) score	0.07

^*From mixed effects models for repeated measures (MMRM) with: (a) predictor variable being change in PROMIS composite score from baseline to 3 months and from 3 months to 12 months, (b) dependent variable being the functional status outcome, and (c) covariates adjusted for in the model being age, sex, medical comorbidity, and socioeconomic disadvantage index.

^†Effect size = change in outcome per 5-point improvement in PROMIS composite score divided by the standard deviation of the outcome at baseline.