Fig. 3.

Overview of EML4-ALK fusions and variants. a EML4-ALK fusion gene is generated by a paracentric inversion on the short arm of chromosome 2. Dotted lines indicate potential fusion sites. b Schematic illustrations of four major EML4-ALK variant proteins, showing where the ALK TK domain is inserted into the EML4 protein. c The individual subdomains that make up the TAPE domain of EML4 are shown. The two propellers of the TAPE domain have thirteen canonical blades and a non-canonical blade comprising the 12N and 12C subdomains. The positions of ALK TK domain insertion into the EML4 structure are shown as black squares, labelled with the variant number. Note that, with the exception of v3 and v5, all variants have ALK inserted into the TAPE domain