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ALK tyrosine kinase inhibitors. Chemical structures of ALK TKIs are shown with the core scaffold highlighted in red. a diaminopyrimidine. b Aminopyridine. c Dihydrobenzocarbazole. d Crystal structure of ALK TK domain (pink cartoon) bound to crizotinib (beige spheres). The image is based on PDB code 2XP2 [71]. Key residues mutated in drug resistance ALK are shown as sticks, coloured teal
