Table 1.

List of EML4-ALK variants

EML4-ALK variant	Gene fusion points	Mutation frequency1	Cell lines	Structural features	References
V1	E13;A20	33 % (25 %)	H3122, DFCI032, STE-1	EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[7, 6, 51, 55]
V2	E20;A20	9 % (7.5 %)		EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[7, 51]
	E20;ins18A20	(<1 %)		EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[108]
V3a	E6a;A20	29 % (18.5 %)2	H2228	EML4- TD, basic No HELP or TAPE ALK TK	[51]
V3b	E6b;A20	29 % (18.5 %)2	H2228	EML4- TD, basic No HELP or TAPE ALK TK	[6, 51]
V4	E15del60;del71A20	2 % (<1 %)		EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[51]
V4′	E14;ins11del49A20	3 % (<1 %)3,5		EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[52]
V5a	E2;A20	2 % (<1 %)4		EML4- TD No basic, HELP or TAPE ALK TK	[52]
V5b	E2;ins117A20	(<1 %)		EML4- TD No basic, HELP or TAPE ALK TK	[52]
V5′	E18;A20	2 % (<1 %)		EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[109]
V6	E13;ins69A20	(<1 %)		EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[110]
V7	E14;del12A20	See V4′ (<1 %)3,5		EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[110]
V8a	E17;ins30A20	(<1 %)6		EML4- TD, basic, HELP motif, incomplete TAPE No functional ALK domain	[111]
V8b	E17ins61;ins34A20	(<1 %)6		EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[111]
	E17;ins68A20	1 % (<1 %)6		EML4- TD, basic, HELP motif, incomplete TAPE ALK TK	[108]
Unknown		19 % (45 %)

¹Mutation frequency obtained from [53] and COSMIC (Catalogue of somatic mutations in cancer), shown in parentheses [112]

²Note that frequency of V3a and V3b are the same because they are splice variants

³Note that V4′ and V7 are combined in the source Ref. [53]

⁴Note that V5a and V5b are combined in the source Ref. [53]

⁵Note that COSMIC lists E14;A20 translocations, but not V4′ and V7

⁶Note that COSMIC lists E17;A20 translocations, but not V8a or V8b