Table 2.
Drug sensitivity or resistance to ALK mutations
| ALK inhibitor | Crizotinib | Ceretinib | Alectinib | PF-06463922 |
|---|---|---|---|---|
| Resistance mutation | ||||
| G1123S | Resistant [113] | Sensitive [113] | ||
| 1151Tins | Resistant [79, 90] | Resistant [90] | Resistant [79] | Sensitive [87] |
| L1152P/R | Resistant [90] | Resistant [90] | Sensitive [114] | Sensitive [87] |
| C1156Y/T | Resistant [90] | Resistant [90] | Sensitive [87] | Sensitive [87] |
| I1171T/N | Resistant [90] | Sensitive [90, 115, 116] | Resistant [115, 116] | Sensitive [87] |
| F1174L/C | Resistant [90] | Resistant [90] | Sensitive [115] | Sensitive [87] |
| V1180L | Resistant [115] | Sensitive [115] | Resistant [115] | Sensitive [87] |
| L1196M | Resistant [78, 79, 83] | Sensitive [90] | Sensitive [87] | Sensitive [87] |
| G1202R | Resistant [79, 90] | Resistant [84, 90] | Resistant [79] | Sensitive [72, 87] |
| S1206Y | Resistant [79, 90] | Sensitive [90] | Sensitive [79] | Sensitive [87] |
| G1269A/S | Resistant [90] | Sensitive [90] | Sensitive [114] | Sensitive [87] |