Table 5.

Multivariate Analyses (linear mixed models) of change in smoking intensity (by difference in cigarette consumption) and changes in plasma total glutathione and total cysteine (all baseline smokers)

	tGSH [μM]		tCys [μM]
	β	95% CL, P-value	β	95% CL, P-value
	Model 1
Smoking status
Continuing smoker and…
Increase in cigarette consumption	−0.18	(−0.63; 0.27); 0.44	−19.9	(−51.1; 11.3); 0.21
Stable cigarette consumption	Ref.		Ref.
Decrease by 1 to 9 cigarettes	−0.07	(−0.37; 0.24); 0.67	−15.8	(−36.9; 5.26); 0.14
Decrease by 10 to 19 cigarettes	−0.04	(−0.38; 0.30); 0.82	−0.69	(−24.4; 23.0); 0.95
Decrease by ≥ 20 cigarettes	−0.33	(−0.83; 0.181); 0.20	−1.58	(−37.0; 33.8); 0.93
Quitter	0.41	(0.03; 0.77), 0.03	−0.19	(−26.2; 25.8); 0.99
N		378		379
	Model 2
Smoking status
Continuing smoker and…
Increase in cigarette consumption	−0.2	(−0.72; 0.31); 0.44	−21.8	(−58.1; 14.6); 0.24
Stable cigarette consumption	Ref.		Ref.
Decrease by 1 to 9 cigarettes	−0.11	(−0.43; 0.22); 0.53	−13.2	(−36.7; 10.3); 0.27
Decrease by 10 to 19 cigarettes	0.05	(−0.33; 0.42); 0.80	−2.3	(−29.1; 24.5); 0.87
Decrease by ≥ 20 cigarettes	−0.32	(−0.84; 0.21); 0.24	−1.3	(−39.1; 36.5); 0.95
Quitter	0.53	(0.11; 0.95), 0.01	2.1	(−28.2; 32.4); 0.89
N		318		319

Model 1: Adjusted for age, sex, education, baseline cigarette consumption, baseline-level of respective parameter (=correction for autocorrelation), and clustering of patients by general practitioner (random effect)

Model 2: like Model 1, but additionally adjusted for baseline level of and change in BMI, and baseline history of diseases (coronary heart disease, diabetes, hypertension, cancer)