Figure 3. Survivin is required for the production of natural antibodies.

(A) Total serum IgM and (B) total serum IgG levels from unimmunized survivin^L/Lcd21^Cre and survivin^+/+cd21^Cre mice. (C) Flow cytometric analysis of peritoneal cavity cells from survivin^L/Lcd21^Cre and survivin^+/+cd21^Cre mice with indicated antibodies. (D) Graphs show total cell numbers in the peritoneal cavity (top panel), the relative frequency of B1a, B1b and B 2 cells in the population of lymphocytes (middle) and the absolute cell numbers of B1a, B1b and B 2 cells (bottom) in the peritoneal cavities of survivin^L/Lcd21^Cre and survivin^+/+cd21^Cre mice.