Table 3.

Median (range) pharmacokinetic parameters for cocaine and benzoylecgonine (BE) in oral fluid (N = 10 participants) following 25 mg intravenous (IV) cocaine administration collected with Oral-Eze (OE) and StatSure (SS) collection devices up to 69 h.

	Oral-Eze		StatSure

	Cocaine	BE	Cocaine	BE
C_max (μg/L)	932 (394–1,574)^*	248 (96.9–953)^*	732 (83.3–1,892)	360 (77.2–836)
T_max (h)	0.34 (0.17–1)^*	0.5 (0.17–1)^*	0.17 (0.17–0.5)	0.5 (0.17–1)
T_1/2 (h)	1.3 (0.6–2.2)^*^†	6.9 (4.4–12.1)^*	0.89 (0.57–1.4)^§^†	6.6 (4.1–14.1)^§
AUC_0-69h (h x μg/L)	802 (314–1,447)	814 (425–1,801)	467 (174–1,378)	670 (390–1,298)
T_last (h)	12.5 (4–69)^*	30.5 (21–69)^*	6.5 (4–45)^§	28 (21–69)^§
C_last (μg/L)	1.9 (1.0–35.1)	2.8 (1.1–20.8)	5.3 (1.0–26.6)	3.5 (1–11.4)

C_max maximum concentration detected, T_max time of maximum concentration, T_1/2 terminal half-life, AUC area under the curve, C_last last detected concentration, T_last time of last detected concentration

Significant difference P < 0.05:

OE cocaine versus BE;

^§

SS cocaine versus BE;

^†

OE versus SS cocaine;

^‡

OE versus SS BE