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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Immunol. 2016 Jan 25;196(5):2300–2308. doi: 10.4049/jimmunol.1500130

Figure 7. A schematic summary of the potential dynamics involved in the sustained systemic inflammation due to subclinical endotoxemia.

Figure 7

Systemic subclinical super-low dose endotoxin may establish a sustained “memory” state of low-grade liver inflammation through the removal of MKP7, sustained activation of the p38/JNK MAPKs signaling circuit, which eventually facilitate the propagation of neutrophil infiltration, MPO release, hepatocyte death, and NASH progression.