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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Drug Discov Today. 2015 Nov 19;21(2):342–347. doi: 10.1016/j.drudis.2015.11.007

Figure 1.

Figure 1

Typical protein denaturation situations encountered in the laboratory. (A) The classical two-state situation in which protein denaturation occurs without the presence of partially denatured conformation. This situation is mostly observed for single-domain proteins or multidomain proteins with highly cooperative interdomain interactions. (B) The situation in which denaturation occurs with the presence of a significantly populated partially denatured state. This situation often occurs with multidomain proteins.