Table 2.

Summary of emerging F-box proteins in cancer

F-box Protein	Disease Link	Abnomalities	Mechanism	Reference
Fbxl10	Pancreatic ductal adenocarcinoma	overexpression	Stimulates histone H2A ubiquitylation in fruit fly Drosophila	(153,154)
Fbxl20	Colorectal adenocarcinoma	overexpression	Promotes carcinogenesis through regulating Wnt signaling and caspase activation, mediates Vps34 ubiquitylation and autophagy, facilitates E-cadherin ubiquitylation and induces invasion	(155–160)
Fbxw8	3-M syndrome		Assembles ubiquitin E3 ligase with Cul7, Skp1 and Roc1, tethers the SCF and CRL7 E3 hetermeric complex	(161–165)
Fbxo4	Cancer, general	mutate	Targets cyclin D1 and TRF1 for degradation	(166–169)
Cyclin F	Hepatocellular carcinoma	low expression	Targets CP110 and RRM2 to control centrosome duplication and maintains genome stability	(23,27,116,118)
Fbxo5	Ovarian clear cell carcinoma	overexpression	Inhibitor of APCCDH1 and APCCDC20	(145,170,171)
Fbxo9	Multiple myelomas	overexpression	Targets degradation of Tel2 and Tti1 and regulates mTOR signaling	(172)
Fbxo10	Associate with breast cancer susceptibility			(173–175)
Fbxo11	B cell lymphoma/breast cancer	mutate or delete	Degrades Bcl6, Cdt2, Snail	(131,132,176)
Fbxo18	melanoma, lung cancer (deleted)	delete or mutate	DNA-dependent ATPase and DNA-unwinding activities, possesses both pro- and anti-recombinogenic activities	(177–179)
Fbxo31	Breast cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma	controversial	Inhibits proliferation and tumorigenesis in breast cancer, hepatocellular carcinoma and ovarian cancer, but overexpressed in lung cancer	(114,180,181)