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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Free Radic Biol Med. 2015 Dec 12;91:215–223. doi: 10.1016/j.freeradbiomed.2015.12.009

Figure 4.

Figure 4

Concentrations of S-nitrosothiols in plasma and the percentage of high molecular weight S-nitrosothiols therein after S-nitrosothiol infusion into the ipsilateral femoral artery (n=5). (A) Concentrations of plasma S-nitrosothiols in the ipsilateral femoral vein (left) and brachial artery (right). (B) Percentage of plasma S-nitrosothiols in high molecular weight form in the ipsilateral femoral vein (left) and brachial artery (right). (C) Percentage of S-nitrosothiols in high molecular weight form at 40 seconds after the addition of L- and D-cysNO and GSNO into PBS (left) and plasma (right). In our intra-arterial infusion model, concentration and molecular weight composition of plasma S-nitrosothiols in the ipsilateral femoral vein was assumed to closely approximate that of the ipsilateral femoral artery, while that in brachial artery was assumed to closely approximate that of the mesenteric and contralateral femoral arteries, where the dilution and S-transnitrosylation of the ipsilaterally applied S-nitrosothiols had already occurred during recirculation.