Table 1.

Summary of histopathological evaluation hepatic aging in WT and Cyp2e1-null mice

	Young WT	Old WT	Young Null	Old Null
Number of animals	8	8	8	8
Hepatocyte vacuolation/steatosis	0	8	0	4
Slight		3		4
Moderate		2
Severe		3
Ballooning degeneration	0	7	0	4
Slight		2		4
Moderate		3
Severe		2
Inflammatory cell infiltration	0	7	0	3
Slight		2		3
Moderate		2
Severe		3
Fibrosis (Sirius Red)	0	7	0	3
Slight		1		1
Moderate		4		2
Severe		2
Necrosis	0	2	0	0
Cholestasis	0	6	0	2

Grading System: slight, few hepatocytes affected; moderate, multiple foci of hepatocytes or the cell surroundings affected; severe, diffuse pan-lobular damage.