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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Immunol. 2016 Feb 1;196(5):2181–2194. doi: 10.4049/jimmunol.1500303

FIGURE 7.

FIGURE 7

IL-6 biases LC Ag presentation to T cells towards an enhanced IL-17A response with a reduced IFNγ and IL-4 response. IL-6 was added to cultures of LCs, T cells (from DO11.10 Tg mice) and cOVA323–339. After 48 hours, supernatants were assessed for cytokine content. Addition of IL-6 significantly enhanced IL-17A production with a significant decrease in IL-4 production. IL-22 production was not affected by IL-6. n=2 experiments, all groups. *p < 0.05, **p < 0.01, ***p < 0.001 compared to no IL-6.