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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Immunol. 2016 Feb 1;196(5):2181–2194. doi: 10.4049/jimmunol.1500303

FIGURE 8.

FIGURE 8

CGRP pretreatment of pDMECs biases BMDC Ag presentation to T cells towards an enhanced IL-17A and IL-6 response with a reduced IFNγ and IL-22 response. Medium- or CGRP-treated pDMECs were added to cultures of BMDCs, T cells (from DO11.10 Tg mice) and cOVA323–339. After 48 hours, supernatants were assessed for cytokine content. Addition of medium-treated pDMECs slightly but significantly enhanced IL-17A and IFNγ (very slightly) production alone with more substantial and significant increases in IL-6, and IL-22. A significant decrease in IL-4 production occurred. Addition of CGRP-treated pDMECs led to a significant increase in IL-17A and IL-6 production, a small but significant decreased production of IFNγ and IL-22 with little or no reduction in IL-4 production compared to that seen in wells with addition of medium-treated pDMECs. n=3 experiments, all groups. *p < 0.05, **p < 0.01, ***p < 0.001.