Table 1.
Genistein absorptive permeability and fraction metabolized (Fm) estimates, and conjugate metabolite excretion parameters.
| Geniste in Permeability (cm/s) | Fm | Metabolite Excretion Rate, Jmet (nmole/s) | Metabolite Clearance, Clexcretion (mL/min) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Apical | Basolateral | Apical | Basolateral | |||||||||
|
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| Condition1 | Mean | % CV | Mean2 | % CV | Mean | % CV | Mean | % CV | Mean | % CV | Mean | % CV |
| Control | 1.3 × 10-5 | 32.7 | 0.47 | 31.3 | 10.5 × 10-5 | 21.8 | 3.7 × 10-5 ** | 15.9 | 2.4 × 10-3 | 11.4 | 0.9 × 10-3 ** | 41.0 |
| Glyceollin | 2.2 × 10-5 * | 3.8 | 0.13* (0.03and 0.23) | 109.1 | 6.5 × 10-5 * | 16.4 | 2.2 × 10-5 | 71.1 | 5.9 × 10-3 * | 60.0 | 0.8 × 10-3 ** | 13.1 |
1
For Control and Glyceollin conditions, genistein permeability and Fm are the averages of 6 filters from two experiments of 3 filters each. Metabolite excretion parameters are also the average of 6 filters from the two experiments for the Controls. For the Glyceollin condition, excretion parameters are the average of 3 filters from the second experiment.
2
In the case of Glyceollin condition, the means for each of the two experiments are also presented in parentheses.
*
Significantly different from Control (p < 0.05).
**
Significantly different from Apical (p < 0.05).