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The regulation of MMPs and their roles in leukemia progression. AP-1: activator protein-1; NFkB: nuclear factor kappa-light-chain-enhancer of activated B cells; STAT: signal transducer and activator of transcription; BM: bone marrow; ECM: extra cellular matrix; GF: growth factor; EGFR: epidermal growth factor; MDS: myelodysplastic syndrome; AML: acute myeloid leukemia; CML: chronic myeloid leukemia.
