Table 2.

Relevant studies concerning the effects of n3-PUFAs in healthy human adults. M = mean age.

Reference No.	Design	Participants	Supplement	Duration	Results
[176]	RCT	49 healthy (M=22-55 years)	DHA (800mg) + EPA (1600mg) + other n-3-PUFAs (400mg)	35 days	Improvement of attentional functions
[177]	RCT, double blind	54 healthy (M=22 years)	DHA (250mg) + EPA (1740), placebo	4 weeks	Effect on reactivity and risky decision-making, but not on attention, memory, response inhibition and emotion recognition
[178]	RCT, double blind	41 healthy (M=20 years)	DHA (480mg) + EPA (720mg), placebo	28 days	Not significant
[179]	RCT, double blind	159 healthy (M=18-35 years	DHA (1000mg or 2000 mg) placebo	12 weeks	Not significant
[180]	RCT, double blind	391 healthy (M= 65-90 years)	DHA (1720 mg) + EPA (600mg), placebo	18 months	Not ended
[68]	RCT, double blind	867 healthy (M= 70-79 years)	DHA (500 mg) + EPA (200mg), placebo	24 months	Not significant
[181]	RCT, double blind	485 healthy (M ≥ 55 years)	DHA (900mg), placebo	24 weeks	Improved learning and memory function
[182]	RCT	50 healthy (M = 60.5 years)	caloric restriction, relative increased intake of PUFA, control	3 months	Not significant for PUFA
[183]	RCT, double blind	49 healthy (M = 60-80 years)	DHA (800 mg), lutein, combination of DHA and lutein	4 months	Improvement of memory
[184]	Longitudinal study	1449 healthy (M = 65-80 years)	No supplement	21 years	High intake of polyunsaturated fatty acids (PUFA) was associated with better semantic memory
[185]	RCT, double blind	302 healthy (M =70 years)	DHA/EPA (1800 or 400mg), placebo	26 weeks	Not significant
[186]	Cross-sectional	1613 healthy (M = 45-70 years)	No supplement		Fatty fish and marine omega-3 PUFA consumption was associated with a reduced risk of impaired cognitive function
[187]	Prospective	5386 healthy (M > 55 years)	No supplement	2,1 years	Fish consumption was inversely related to incident dementia and in particular to Alzheimer's disease