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. 2015 May 11;35(7):827–832. doi: 10.1038/onc.2015.153

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Lung epithelial cells. (a) Bronchioalveolar stem cells (BASCs) give rise to bronchiolar epithelial cells (BSC or Clara cells) and alveolar epithelial cells (ASC or AT2 cells), which are involved in tissue renewal. BASCs express both BSC-specific markers (CC10) and ASC-specific markers (SP-C). BSCs generate BSCs, Clara cells, goblet cells and ciliated cells, whereas AT2 cells generate AT2 and AT1 cells. (b) BASCs, BSCs and AT2 cells are the known cells of origins of lung adenomas/adenocarcinomas.