Table 1.
Protein name | UniProtKB ID |
Gene | Molecular function | Biological process | Subcellular location | Family | Function |
---|---|---|---|---|---|---|---|
Vascular endothelial growth factor | P15692 | VEGFA | Developmental protein, growth factor, mitogen | Angiogenesis, differentiation | Secreted | PDGF/VEGF growth factor family | Growth factor active in angiogenesis, vasculogenesis, and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels |
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Macrophage colony-stimulating factor | P09603 | CSF1 | Cytokine, growth factor | Immunity, inflammatory response, and innate immunity | Cell membrane, membrane, secreted | U/A | Cytokine that plays an essential role in the regulation of survival, proliferation, and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes |
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Stromal cell-derived factor-1 | P48061 | CXCL12 | Cytokine, growth factor | Chemotaxis | Secreted | Chemokine CC family | Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils |
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Transforming growth factor-β | P01137 | TGFB1 | Growth factor, mitogen | U/A | Extracellular matrix, secreted | TGF-beta family | Multifunctional protein that controls proliferation, differentiation, and other functions in many cell types |
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Tumor necrosis factor-α | P01375 | TNF | Cytokine | U/A | Cell membrane, membrane, secreted | Tumor necrosis factor family | It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines |
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Interleukin-1 | P01583 | IL1A | Cytokine, mitogen, and pyrogen | Inflammatory response | Secreted | IL-1 family | Produced by activated macrophages; IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity |
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Interleukin-6 | P05231 | IL-6 | Cytokine, growth factor | Acute phase | Secreted | IL-6 family | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation |
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Hepatopoietin-A | P14210 | HGF | Growth factor, serine protease homolog | U/A | U/A | Peptidase S1 family | Is potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types |
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Insulin growth factor-1 | P05019 | IGF1 | Growth factor | U/A | Secreted | Insulin family | The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity |
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Matrix metalloproteinase-2 | P08253 | MMP2 | Hydrolase, metalloprotease, and protease | Angiogenesis, collagen degradation | Cytoplasm, extracellular matrix, membrane, mitochondrion, nucleus, secreted | Peptidase M10A family | Ubiquitous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture |
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Interleukin-8 | P10145 | CXCL8 | Cytokine | Chemotaxis, inflammatory response | Secreted | Chemokine CxC family | IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation |