Table 3.

The characterization of specific secretory proteins in ASC-CM.

Protein name	UniProtKB ID	Gene	Molecular function	Biological process	Subcellular location	Family	Function
Fibroblast growth factor-1	P05230	FGF1	Developmental protein, growth factor, mitogen	Angiogenesis, differentiation	Cytoplasm, nucleus, secreted	Heparin-binding growth factors family	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation, and cell migration
Granulocyte colony-stimulating factor	P09919	CSF3	Cytokine, growth factor	U/A	Secreted	IL-6 family	Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes, and the monocytes-macrophages
Granulocyte-macrophage colony-stimulating factor	P04141	CSF2	Cytokine, growth factor	U/A	Secreted	GM-CSF family	Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils, and erythrocytes
Pigment epithelium-derived factor	P36955	SERPINF1	U/A	U/A	Secreted	Serpin family	Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells
Metalloproteinase inhibitor 1	P01033	TIMP-1	Growth factor, metalloenzyme inhibitor, metalloprotease inhibitor, and protease inhibitor	U/A	Secreted	Protease inhibitor I35 family	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor
Plasminogen activator inhibitor 1	P05121	SERPINE1	Protease inhibitor, serine protease inhibitor	U/A	Secreted	Serpin family	Serine protease inhibitor
Connective tissue growth factor	P29279	CTGF	U/A	Cell adhesion, DNA synthesis	Extracellular matrix, secreted	CCN family	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes
Collagen alpha-2(I) chain	P08123	COL1A2	U/A	U/A	Extracellular matrix, secreted	Fibrillar collagen family	Type I collagen is a member of group I collagen (fibrillar forming collagen)
Collagen alpha-1(VI) chain	P12109	COL6A1	U/A	Cell adhesion	Extracellular matrix, secreted	Type VI collagen family	Collagen VI acts as a cell-binding protein
Fibronectin	P02751	FN1	U/A	Acute phase, angiogenesis, cell adhesion, and cell shape	Extracellular matrix, secreted	U/A	Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape