Skip to main content
. 2016 Feb 1;32(2):194–202. doi: 10.1089/aid.2015.0211

FIG. 1.

FIG. 1.

Reconstitution of human immune cells in human peripheral blood mononuclear cells (hu-PBMC)-NSG mice. (A) The percentage of human CD45+ T cells in the peripheral blood of hu-PBMC-NSG mice (n = 20) reconstituted with human PBMCs 4 to 10 weeks after intraperitoneal injection. (B) The percentage of human CD3+ T cells in the peripheral blood of hu-PBMC-NSG mice increased significantly 28 days after intraperitoneal injection (p < 0.01). (C) CD4+/CD3+ and (D) CD8+/CD3+ T cell ratios in peripheral blood from NSG mice injected intraperitoneally with 1 × 107 human PBMCs (n = 20). Results are expressed as means ± standard deviation (error bars); n.s., not significant (p > 0.05). Mice were bled at the indicated time points after injection of human PBMCs, and PBMCs were isolated for quantification of cell subsets by flow cytometry.