Table 3.
Unadjusted and Adjusted Associations Between Cytomegalovirus and Inflammatory Markers by HIV-1 Status
HIV uninfected, N = 54 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
IL-6 plasma | IL-6 CVL | sCD1 | sCD163 | IP10 | ||||||
ρa | p-value | ρa | p-value | ρa | p-value | ρa | p-value | ρa | p-value | |
Unadjusted association | 0.24 | 0.081 | −0.13 | 0.344 | 0.10 | 0.471 | 0.10 | 0.470 | 0.21 | 0.133 |
False discovery rate adjusted p-value | 0.238 | 0.430 | 0.471 | 0.471 | 0.249 | |||||
Adjustment variables | ||||||||||
Age | 0.20 | 0.148 | 0.05 | 0.717 | −0.02 | 0.861 | −0.005 | 0.974 | 0.002 | 0.990 |
CD4 | 0.17 | 0.247 | −0.19 | 0.191 | 0.12 | 0.409 | 0.08 | 0.572 | 0.21 | 0.145 |
HCV | 0.24 | 0.092 | −0.17 | 0.235 | 0.12 | 0.390 | 0.08 | 0.594 | 0.19 | 0.168 |
BMI | 0.18 | 0.190 | −0.17 | 0.223 | 0.11 | 0.423 | 0.04 | 0.774 | 0.19 | 0.175 |
eGFR | 0.17 | 0.224 | −0.04 | 0.778 | 0.03 | 0.807 | 0.08 | 0.586 | 0.20 | 0.162 |
Smoking | 0.21 | 0.136 | −0.18 | 0.202 | 0.11 | 0.442 | 0.09 | 0.534 | 0.20 | 0.141 |
Hypertension | 0.15 | 0.286 | −0.12 | 0.378 | 0.04 | 0.801 | 0.003 | 0.985 | 0.12 | 0.405 |
Black race | 0.20 | 0.159 | −0.10 | 0.498 | 0.07 | 0.634 | 0.07 | 0.613 | 0.21 | 0.139 |
HIV aviremic, N = 58 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
IL-6 Plasma | IL-6 CVL | sCD14 | sCD163 | IP10 | ||||||
ρa | p-value | ρa | p-value | ρa | p-value | ρa | p-value | ρa | p-value | |
Unadjusted association | 0.21 | 0.114 | −0.10 | 0.450 | 0.27 | 0.039 | 0.17 | 0.193 | 0.15 | 0.261 |
False discovery rate adjusted p-value | 0.244 | 0.471 | 0.146 | 0.290 | 0.356 | |||||
Adjustment variables | ||||||||||
Age | 0.20 | 0.133 | −0.05 | 0.702 | 0.23 | 0.082 | 0.12 | 0.370 | 0.11 | 0.424 |
CD4 | 0.24 | 0.069 | −0.09 | 0.504 | 0.29 | 0.026 | 0.15 | 0.281 | 0.13 | 0.323 |
HCV | 0.17 | 0.213 | −0.10 | 0.479 | 0.27 | 0.041 | 0.15 | 0.251 | 0.09 | 0.524 |
BMI | 0.21 | 0.119 | −0.12 | 0.378 | 0.30 | 0.025 | 0.17 | 0.203 | 0.15 | 0.257 |
eGFR | 0.21 | 0.116 | −0.11 | 0.436 | 0.28 | 0.038 | 0.18 | 0.190 | 0.15 | 0.259 |
Smoking | 0.21 | 0.126 | −0.09 | 0.488 | 0.26 | 0.049 | 0.20 | 0.127 | 0.16 | 0.231 |
Hypertension | 0.15 | 0.274 | −0.13 | 0.332 | 0.26 | 0.047 | 0.14 | 0.304 | 0.12 | 0.356 |
Black race | 0.21 | 0.116 | −0.09 | 0.499 | 0.30 | 0.022 | 0.19 | 0.168 | 0.18 | 0.187 |
HIV viremic, N = 52 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
IL-6 plasma | IL-6 CVL | sCD14 | sCD163 | IP10 | ||||||
ρa | p-value | ρa | p-value | ρa | p-value | ρa | p-value | ρa | p-value | |
Unadjusted association | 0.31 | 0.023 | −0.32 | 0.021 | 0.43 | 0.002 | 0.23 | 0.095 | 0.20 | 0.150 |
False discovery rate adjusted p-value | 0.115 | 0.115 | 0.030 | 0.238 | 0.250 | |||||
Adjustment variables | ||||||||||
Age | 0.26 | 0.064 | −0.26 | 0.069 | 0.33 | 0.018 | 0.16 | 0.252 | 0.15 | 0.286 |
CD4 | 0.30 | 0.036 | −0.30 | 0.036 | 0.40 | 0.005 | 0.23 | 0.114 | 0.16 | 0.277 |
Viral load | 0.29 | 0.036 | −0.33 | 0.021 | 0.42 | 0.002 | 0.20 | 0.160 | 0.16 | 0.264 |
cART since last visit | 0.28 | 0.047 | −0.23 | 0.105 | 0.35 | 0.011 | 0.29 | 0.040 | 0.20 | 0.150 |
HCV | 0.28 | 0.045 | −0.25 | 0.082 | 0.39 | 0.005 | 0.16 | 0.272 | 0.12 | 0.424 |
BMI | 0.31 | 0.033 | −0.33 | 0.024 | 0.39 | 0.007 | 0.23 | 0.127 | 0.19 | 0.193 |
eGFR | 0.20 | 0.151 | −0.26 | 0.064 | 0.24 | 0.087 | 0.08 | 0.590 | 0.16 | 0.262 |
Smoking | 0.24 | 0.091 | −0.30 | 0.034 | 0.36 | 0.011 | 0.25 | 0.084 | 0.17 | 0.234 |
Hypertension | 0.24 | 0.083 | −0.35 | 0.012 | 0.39 | 0.005 | 0.23 | 0.111 | 0.18 | 0.216 |
Black race | 0.31 | 0.025 | −0.33 | 0.021 | 0.43 | 0.002 | 0.24 | 0.092 | 0.20 | 0.152 |
Spearman rank correlation coefficient.