. 2016 Feb 22;6:21827. doi: 10.1038/srep21827

Table 1. SCMs in liver induced by TPhP.

	SCMs	0.050 mg/L		0.300 mg/L
	SCMs	Fold Change	VIP score	Fold Change	VIP score
carbohydrate metabolism	Fumarate	0.73^*	1.07	0.69^*	1.23
	Glucose	1.41^**	1.23	1.39^*	1.26
	Glycolate	0.88	0.58	0.57^**	1.63
	Lactate	0.68^**	1.32	0.86	0.66
	Succinate	0.68^*	1.15	0.75	0.90
	UDP-glucose	0.57^**	1.66	1.21^*	0.84
lipid and fatty acid metabolism	Choline	0.55^**	1.77	0.80^**	1.04
	Acetylcarnitine	0.68^**	1.32	0.73^**	1.22
	Esterified Cholesterol	0.64^**	1.43	0.55^**	1.76
	FA-ARA+EPA	1.44^**	1.31	1.21^*	0.83
	FA-LINOLEIC	0.81^*	0.89	0.76^**	1.11
	FA-αH₂	0.72^**	1.24	0.75^*	1.09
	Phosphatidylserine	0.52^*	1.64	0.31^**	2.48
amino acid metabolism	Alanine	0.43^**	2.06	0.60^**	1.54
	Glutamate	0.66^**	1.41	0.67^**	1.43
	Glutamine	0.64^**	1.41	0.73^*	1.04
	Leucine	1.77^**	1.62	1.99^**	1.85
TMAO metabolism	Dimethylamine	1.88^**	1.72	2.89^**	2.46
TMAO metabolism	Trimethylamine-N-oxide (TMAO)	0.90	0.49	0.56^**	1.65

SCMs were identified by performing PLS-DA analysis and t-tests between TPhP-treated groups and the control group (n = 6) using MetaboAnalyst 3.0. VIP scores were obtained from PLS-DA models with a threshold of 1.0. Asterisk (*) and double asterisks (**) denote significant treatment effects identified by Student’s t-test (p < 0.05 and p < 0.01, respectively) relative to controls. The fold change was obtained by comparing relevant metabolites in the TPhP groups with the control group. SCMs in liver induced by TPhP.