Table 1. Compounds 1–4: Activity against Src and ADME properties^a.

Cpd	Aqueous Solubility (μg/mL)	LogPb	Src (Ki μM)	PAMPA (10−6 cm2/sec)	MRc (%)	Metabolic Stabilityd (%)
1	0,21	6,555	3.7	3.98	46.8	95.8
2	3,71	5,813	0.13	5.27	46.1	96.0
3	0,22	5,678	0.4	5.51	48.9	97.9
4	0,90	5,992	0.01	4.53	49.6	93.5

^aAll the data were previously reported, see supporting material for experimental details²⁵,²⁶,²⁷.

^bCalculated by Qikprop.

^cMembrane Retention (MR) expressed as percentage of compound unable to reach the acceptor compartment.

^dExpressed as percentage of unmodified drug.