Table 3. Cytotoxicity in SH-SY5Y NB cells.
| Cpd/Formulation | IC50 24 h (μM) | IC50 48 h (μM) | IC50 72 h (μM) |
|---|---|---|---|
| 1 | 21.84 ± 1.70 | 16.5 ± 1.67 | 13.54 ± 2.00 |
| LP-1 | 8.03 ± 0.59 | 7.14 ± 1.90 | 6.35 ± 1.44 |
| 2 | 12.6 ± 1.6 | 2.66 ± 0.015 | 2.28 ± 0.29 |
| LP-2 | 6.80 ± 0.98 | 1.74 ± 0.31 | 0.94 ± 0.68 |
| 3 | 3.04 ± 0.09 | 2.65 ± 0.08 | 1.54 ± 1.07 |
| LP-3 | 3.50 ± 0.17 | 1.52 ± 0.94 | 1.54 ± 0.79 |
| 4 | 13.64 ± 0.94 | 10.06 ± 0.50 | 8.63 ± 0.75 |
| LP-4 | 3.87 ± 0.51 | 1.91 ± 1.46 | 1.90 ± 0.46 |
| AL-4 | 20.04 ± 1.04 | 12.02 ± 0.97 | 12.03 ± 0.30 |
SH-SY5Y cells were seeded at 105 cells/well density. The cultures were maintained at 37 °C in 5% v/v CO2 for 24, 48 and 72 h. IC50s were evaluated by Trypan blue assay and calculated by GraphPad Prism 6.0 software using the best fitting sigmoid curve.