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. 2016 Feb 22;10:16. doi: 10.3389/fnana.2016.00016

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Copyright © 2016 Steinemann, Galm, Chip, Nitsch and Maly.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical stainings of horizontal cryosections of the developing brain (E14 and E18). Occludin immunoreactivity (A,D) is present in brain vessels and in epithelium of choroid plexus and ZO-1 (B,E) in brain vessels and in the neuroepithelium of the ventricle. Claudin-5 immunoreactivity (C,F) is selectively present in the endothelium of brain vessels. Anti-claudin-1 (G,K), anti-claudin-2 (H,L) and anti-claudin-3 (I,M) do not stain any blood vessels but the epithelium of the choroid plexus. Immunoreactivity for claudin-3 is strong from E14 onward, for claudin-1 faint at E14 and comparable with claudin-3 at E18, and for claudin-2 it only appears at E18. LV, lateral ventricle; Hi, Hippocampus, green arrow choroid plexus, red arrow blood vessel, black arrow ependyma. Scale bar = 100 μm in (A) applies also for (B–M).