Table 7:
Reperfusion in Included RCTs
| Author, Year | Intervention | Control | Effect Variable | Unadjusted Value (95% CI) | Adjusted Value (95% CI) |
|---|---|---|---|---|---|
| Berkhemer et al, 201527 | 115/196 (58.7)a | NR | NR | NR | NR |
| Campbell et al, 201528 | 100 (100–100)b | 37 (−0.5 to 96) | Odds ratio | 4.9 (2.5–9.5)c | 4.7 (2.5–9.0)c |
| Goyal et al, 201529 | 113/156 (72.4)a: 79/112 (70.5) with IVT 34/44 (77) without IVT |
NR | NR | NR | NR |
| Jovin et al, 201530 | 67/102 (65.7)a | NR | NR | NR | NR |
| Saver et al, 201531 | 73/83 (88)a 53/64 (83)d |
NR 21/52 (40) |
NR Risk ratio |
NR 2.05 (1.45–2.91)c |
NR NR |
Abbreviations: CI, confidence interval, IVT, intravenous thrombolysis, NR, not reported; RCT, randomized controlled trial; TICI, Thrombolysis in Cerebral Infarction.
Reperfusion was measured by the TICI score, where a score of 2b or 3 indicated complete filling of the expected vascular territory: number/total number (%).
Reperfusion was defined as the percentage reduction in the perfusion-lesion volume between initial imaging and 24-hour imaging (interquartile range). This value can be negative if hypoperfusion becomes more severe over time. This analysis was adjusted for the site of vessel occlusion at baseline.
P<0.001.
Saver et al (32) also reported successful reperfusion at 27 hours: number/total number (%). Successful reperfusion was defined as reperfusion of at least 90%, as assessed with the use of perfusion computed tomography or magnetic resonance imaging. Data on successful reperfusion were not obtained for all patients after the adoption of the protocol amendment making penumbral imaging optional.