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. 2016 Feb 22;6:21598. doi: 10.1038/srep21598

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Two heatmaps showed the expression patterns of circadian miRNA primary transcripts from Nascent-seq and GRO-seq respectively. High (red) and Low (blue) expression values as Z-scored normalized ratios are indicated in the color scale bar at the bottom. Black/white bars indicate the circadian day (white) and night (black) of the consecutive circadian cycles. (b) Expression patterns of circadian miRNA primary transcripts validated by qPCR. The x-axis represents the circadian time (CT), while the y-axis represents the relative expression values normalized by those of Actb. The white regions represent subjective day while the gray regions represent subjective night.