Table 3. Signature molecules of SDN-, DEP-, DEG- and CF-based classifiers in three clinical settings.

Classifier	Signature molecules
ESCC vs. N
SDN-based	EIF2S1	YWHAH	RPLP2	RBM8A	PSMD2
	RPL3	YBX1	ACTN1	KHDRBS1
DEP-based	RALY	CRNN	DDOST	CCT5	CRABP2
	RPLP2	CTSB
DEG-based	CKS1B	COL1A1	CEP55
CF-based	CKS1B	COL1A1	CEP55
Early vs. late TNM stages
SDN-based	RPL7	CAV1	ITGB1	RPS18	RPL3
	KHDRBS1	RPS6	STAT3	RPLP2	YBX1
	RPL12	RUVBL1	STAT1	PPP2R1A	SF3B3
DEP-based	HTATSF1	TGM3	AKAP12	IVL	CCT5
	RALY	CTSB	MUC5B
	MCM2	FZD6	CBX3	AGRN	MCM6
DEG-based	COL1A1	FSCN1	BID	RANBP1	PDIA6
	MFAP2	ACLY	SNAI2	CDH11	EFNA1
	ATR
CF-based	HTATSF1	TGM3	AKAP12	CBX3	PDIA6
	MCM6	MCM2	AGRN
Responders vs. non-responders
SDN-based	YBX1	EIF2S1	SF3B3	YWHAE	YWHAZ
DEP-based	DDOST	TXN	SPRR3	TPM2	SLC9A3R1
	CRNN	KRT17	CCT5	RPSA	PKP3
	TFRC
DEG-based	MMP1	FANCI	PLAU	FSCN1	PTK7
	BID	KIF2C	CRYL1	GINS1	UBE2C
	YBX1	DDOST	FANCI	TPM2	PLAU
CF-based	TXN	SPRR3	PTK7	MMP1	TFRC
	EIF2S1	KIF2C