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. 2016 Feb 22;6:21316. doi: 10.1038/srep21316

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(A) The conversion of testosterone, to 6β-hydroxy testosterone as a measurement of the enzymatic activity of CYP3A4 was determined by HPLC in the presence of the indicated amounts of c-SWCNTs. (B) Citrate-coated silver nanoparticles also inhibit the enzymatic activity of CYP3A4. Data are shown as mean values ± S.D. (C) Interaction between CYP3A4 protein and c-SWCNTs. Supernatants were taken after incubation of recombinant human CYP3A4 and c-SWCNTs at the indicated concentrations for 60 min and analyzed by SDS-PAGE. The results show that the CYP3A protein is adsorbed by c-SWCNTs (25 µg/mL).