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. 2016 Feb 22;6:21371. doi: 10.1038/srep21371

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Copyright © 2016, Macmillan Publishers Limited

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(a) Possible imaging procedure for OSCC detection using a PARPi-FL based, orally applied solution. Imaging of the oral cavity with a fluorescence camera will be conducted after a one minute topical PARPi-FL application, followed by removal of unbound or non-specifically bound compound with the clearing solution 1% acetic acid. The illustration is courtesy of MSK. (b) Spectrally resolved epifluorescence imaging of healthy mice and tongue tumor bearing mice before and after topical application of PARPi-FL. The tdTomato signal indicates the position of the tumor, while the PARPi-FL signal shows the ability of PARPi-FL to specifically detect sites of OSCC after topical application. All images are scaled to the same maximum radiant efficiency. (c) Epifluorescence imaging of healthy mice and mice bearing orthotopic tongue tumors. The tumors express tdTomato fluorescent protein, as control for tumor localization. Imaging of PARPi-FL signal was conducted before and after PARPi-FL topical application. (d) Confocal microscopy of an OSCC bearing tongue after topical application of PARPi-FL in vivo. Green: PARPi-FL, blue: Hoechst DNA stain. H&E confirms presence of tumor. Arrows point to enlarged images of the squared area.