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Antibody-dependent cell-mediated cytotoxicity induces cytotoxic effect in DAOY cells. Trypan blue staining showed a cytotoxic effect by treatment with a CNTFRα specific antibody and complement serum. The DAOY cells were lysed after 6 hours of treatment, which increased with 24 hours. Immunoglobulin G served as a negative control, underlining the necessity of the anti–CNTFRα antibody in DAOY ADCC. The U87 and HeLa cells (both lacking CNTFRα) were not affected by treatment.
