TABLE 3.
Analysis of factors associated with tumor behavior*
| Outcome Measure & Factor | p Value |
|---|---|
| total tumor burden (no. of tumors; 225 patients) | |
| age | NS |
| yrs of follow-up | 0.0070 |
| sex | 0.002 |
| mutation† | 0.0021 |
| partial deletion | reference |
| deletion | 0.0667 |
| frameshift | 0.0450 |
| missense | 0.0046 |
| nonsense | 0.2508 |
| new tumor development (no. of tumors; 225 patients) | |
| sex | NS |
| mutation† | NS |
| no. of tumors at study entrance | <0.0001 |
| age in yrs | <0.0001 |
| 12–20 | reference |
| 21–30 | 0.0224 |
| 31–40 | 0.0005 |
| 41–50 | <0.0001 |
| >50 | <0.0001 |
| tumor growth rate (mm3/yr; 2505 tumors) | |
| age | NS |
| mutation† | NS |
| sex | 0.0014 |
| tumor location | <0.0001 |
| tumor symptom type | <0.0001 |
| tumor location × tumor symptom type | 0.0001 |
| cerebellum tumor growth rate (mm3/yr; 1156 tumors) | |
| age | NS |
| mutation† | NS |
| sex | NS |
| cyst-linked tumor type | <0.0001 |
| tumor symptom type | <0.0001 |
| cyst-linked tumor type × tumor symptom type | <0.0001 |
| cerebellum cyst growth rate (mm3/yr; 175 cysts) | |
| sex | NS |
| mutation† | NS |
| age (continuous) | 0.0079 |
| tumor symptom type | <0.0001 |
| cyst type | NS |
| tumor symptom type × cyst type | 0.0342 |
*
Linear or linear mixed models were performed to evaluate the association of factors with outcome measures. Age, sex, and mutation would be dropped from the model if they were not significant based on a significance level of 0.1.
NS = not significant.
†
Genotype was available for 197 of the 225 patients.