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. Author manuscript; available in PMC: 2017 Feb 19.
Published in final edited form as: Circ Res. 2016 Feb 19;118(4):620–636. doi: 10.1161/CIRCRESAHA.115.306301

Figure 4. Endothelial Atheroprotective Genes and Vascular Homeostasis.

Figure 4

The expression of atheroprotective genes in vascular endothelium is regulated by key transcriptional factors (e.g., KLF2, KLF4, Nrf2) in response to hemodynamic, hormonal and environmental stimuli. The coordination of this genetic program is further influenced by miRNAs, epigenetic modifications, and pharmacologic agents. The resultant vasoprotective endothelial phenotype supports a spectrum of functions critical to the maintenance of vascular homeostasis.