Figure 1. Cross-sections of different stages of lesions.

A-B. Cross-sections of lesions in the brachiocephalic artery of Ldlr^−/− mice fed a high-fat diet. A. Early fatty streak lesion with some smooth muscle cell involvement. B. Advanced lesion containing large necrotic cores in macrophage-rich areas. Macrophages are visualized by anti-Mac-2 immunohistochemistry (brown reaction product) on adjacent sections. C-D. Cross-sections of lesions of human coronary arteries. C. Pathologic intimal thickening with macrophages. D. Human advanced lesion (late fibroatheroma with macrophages and necrotic core). Macrophages are visualized by anti-CD68 immunohistochemistry (brown reaction product) on adjacent sections. Panels C-D are from Atherosclerosis, 241, Otsuka et al.¹⁴⁰ Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: A pathology study, pages 772-82, Copyright (2015), with permission from Elsevier. Sections were stained by Movat’s pentachrome. Scale bar, 100 μm (A-B); 1 mm (C-D).