Fig. 1.

EM micrographs of conventional chemically fixed ultrathin sections of Hela cells and isolated nuclei. A, B Low magnification images of Hela cells. The nuclear membrane (NM) of nucleus (Nu) is indicated and the nucleolus (NOR) can be observed. C Enlarged view of the region highlighted in (B). The chromatin-like fibers with longitudinal section and cross section orientations are indicated by red boxes and red circles, respectively. The distinguishable nucleosome-like densities are indicated by yellow arrowheads. D EM image of isolated nuclei ultrathin section. The chromatin-like fibers and nucleosome-like densities are highlighted as in C