Table 1.

Group-specific modification reagents used to affect mCRP- aggregated IgG interactions

Amino acid group targeted	Group modification reagent	Reaction of aggregated IgG with group-modified mCRP	Reaction of mCRP with group-modified aggregated IgG
Epsilon amino group of lysine	NHS biotin	Strong binding	No binding
Guanidino group of arginine	p-hydroxyphenylglyoxal	Strong binding	Strong binding
Indole ring of tryptophan	BNPS-Skatole	Decreased binding	Strong binding
Phenyl ring of Tyrosine	Tetranitromethane	Strong binding	Decreased binding
Carboxyl groups of aspartic and glutamic acid	Diazo nor-leucine methylester	Decreased binding	Strong binding
Sulfhydryl group of cysteine	N-ethyl maleimide	Strong binding	Strong binding
Thiomethyl group of Methionine	Hydrogen peroxide	Strong binding	Strong binding

As summarized from studies reported by Motie et al. (1996)