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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2015 Sep 16;14(12):2901–2908. doi: 10.1158/1535-7163.MCT-15-0217

Figure 1. IR triggers a temporary, reversible perturbation in cellular reducing potential.

Figure 1

A) Model of hypothesized effects of IR on cellular reducing equivalents. B) Effects on the cellular NADH/NAD+ ratio following exposure to increasing doses of IR. C) Dose-dependent changes in the cellular NADH/NAD+ ratio following exposure to increasing IR doses were reversed by treatment with NAC in a concentration-dependent manner. * indicates p-value < 0.05 compared to corresponding control condition. All values normalized to corresponding control condition (1.0). Each experiment was carried out at least in triplicate, with values indicating means and error bars representing standard deviation.