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. Author manuscript; available in PMC: 2016 Aug 18.
Published in final edited form as: Nature. 2016 Feb 1;530(7590):298–302. doi: 10.1038/nature16940

Figure 2. Prp8 and U4/U6 and U5 snRNAs.

Figure 2

a, Domain structure of Prp824: HB, helix bundle; RT, Reverse Transcriptase-like; Endo, Endonuclease-like; RH, RNaseH-like; JM, Jab1/MPN. b, Prp8 makes extensive interactions with U4/U6 and U5 snRNAs. c, The α-helix (residues 703-735) of the N-terminal domain fits into the minor groove of U5 snRNA and an extended polypeptide (residue 535-543) fits into the major groove on the opposite face, harnessing the RNA helix firmly in place. d, orthogonal view. U5 snRNA loop 1 interacts with the single-stranded region of U6 snRNA. e, The region around the ACAGAGA sequence forms a hairpin and is sandwiched between the Large and N-terminal domains of Prp8 and Dib1.