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. Author manuscript; available in PMC: 2016 Aug 18.
Published in final edited form as: Nature. 2016 Feb 1;530(7590):298–302. doi: 10.1038/nature16940

Figure 4. Interactions of U4/U6 snRNAs with proteins.

Figure 4

a, Overview of U4/U6 di-snRNP. b, the extraordinary structure of Prp3 and its multiple interactions with U4/U6 snRNA, Prp4, Snu13, the RNaseH-like domain of Prp8, Brr2 N-terminal domain and the LSm core domain. c, The C-terminal region of Prp31 extends along U4 snRNA 5′-stem towards the three-way junction. d, The C-terminal extension of Prp31 makes multiple interactions with U4/U6 snRNAs, Dib1, Prp8 α-finger and the N-terminal extension of Prp6. e, the Prp4 WD40 domain and Prp31 interact with the C-terminal TPR domain of Prp6.