Extended Data Table 1.
Summary of model building of tri-snRNP components
| protein | total residues | M.W. | Modeled | Chain name | Local map | Human/S. pombe names | |
|---|---|---|---|---|---|---|---|
| U5 snRNP | Prp8 | 2413 | 279,299 | 110-2401 | A | 108-735: Foot 751-2104: Body 2147-2401: Head |
220K/Spp42 |
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| Brr2 | 2163 | 246,125 | 364-2163 | B | 363-433: Body 439-2163: Head |
200K/Brr2 | |
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| Snu114 | 1008 | 114,025 | 102-989 | C | Foot | 116K/Cwf10 | |
|
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| Dib1 | 143 | 16,774 | 2-137 | D | Body | 15K/Dim1 | |
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| SmB | 196 | 22,403 | 4-102 | b | SmB/SmB | ||
| SmD3 | 110 | 11,229 | 1-109 | d | SmD3/SmD3 | ||
| SmD1 | 146 | 16,288 | 15-108 | h | SmD1/SmD1 | ||
| SmD2 | 110 | 12,856 | 4-85 | i | Foot | SmD2/SmD2 | |
| SmE | 94 | 10,373 | 4-92 | e | SmE/SmE | ||
| SmF | 96 | 9,659 | 12-83 | f | SmF/SmF | ||
| SmG | 77 | 8,479 | 2-76 | g | SmG/SmG | ||
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| U5 snRNA-L | 214 | 68,847 | 4-173 | U | 4-173: Foot 88-107: Body |
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| U4/U6 snRNP | Snu13 | 126 | 13,570 | 3-126 | K | Body | 15.5K/Snu13 |
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| Prp31 | 494 | 56,305 | 43-457 | F | Body | 61K/Prp31 | |
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| Prp3 | 469 | 55,877 | 150-467 | G | Body | 90K/Prp3 | |
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| Prp4 | 465 | 52,425 | 109-465 | H | Body | 60K/Rna4 | |
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| SmB | 196 | 22,403 | 4-102 | k | SmB/SmB | ||
| SmD1 | 146 | 16,288 | 1-118 | l | SmD1/SmD1 | ||
| SmD2 | 110 | 12,856 | 15-108 | m | SmD2/SmD2 | ||
| SmD3 | 110 | 11,229 | 4-85 | n | Head | SmD3/SmD3 | |
| SmE | 94 | 10,373 | 10-92 | p | SmE/SmE | ||
| SmF | 96 | 9,659 | 12-83 | q | SmF/SmF | ||
| SmG | 77 | 8,479 | 2-76 | r | SmG/SmG | ||
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| Lsm2 | 95 | 11,164 | 1-90 | 2 | Lsm2/Lsm2 | ||
| Lsm3 | 89 | 10,020 | 3-79 | 3 | Lsm3/Lsm3 | ||
| Lsm4 | 172 | 20,304 | 1-90 | 4 | Lsm4/Lsm4 | ||
| Lsm5 | 93 | 10,415 | 4-84 | 5 | Arm | Lsm5/Lsm5 | |
| Lsm6 | 86 | 9,396 | 11-84 | 6 | Lsm6/Lsm6 | ||
| Lsm7 | 115 | 13,010 | 26-105 | 7 | Lsm7/Lsm7 | ||
| Lsm8 | 109 | 12,385 | 1-67 | 8 | Lsm8/Lsm8 | ||
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| U4 snRNA | 160 | 51,390 | 1-152 | V | 1-67: Body 73-152: Head |
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| U6 snRNA | 112 | 36,088 | 1-112 | ! | 1-26: Foot 26-88: Body 108-112: Arm |
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| tri-snRNP specific | Prp6 | 899 | 104,234 | 155-898 | J | Body | 102K/Prp1 |
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| Snu66 | 587 | 66,426 | 5-560 (poly-Ala) | E | Head | 110K/Snu66 | |
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| Prp38 | 242 | 27,957 | Not modeled | hPrp38/Prp38 | |||
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| Snu23 | 194 | 22,682 | Not modeled | hSnu23/Snu23 | |||
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| Spp381 | 291 | 33,764 | Not modeled | ||||