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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Exp Neurol. 2016 Jan 13;277:275–282. doi: 10.1016/j.expneurol.2016.01.008

Figure 4. TSC survival is associated with the level of NMJ innervation.

Figure 4

(A) Immuno-labeling of TSCs using anti-S100β and 4E2 (Schwann cell associated antigen) antibodies. S100β and 4E2-positive TSCs overlapped with pre-synaptic area of endplates (arrows) in pre-symptomatic rats. However, these positive signals were weak or undetectable in end-point animals (arrowheads). (B) The number of S100β-positive endplates was significantly decreased at symptomatic (Sympt) and end-stage compared to pre-symptomatic stage (Pre-sympt). (C) The reduction of S100β-positive endplates was associated with the level of innervated endplates. Scale bar: 20 μm. *: P<0.05 vs. pre-symptomatic. n.d.: not detected.