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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Exp Neurol. 2016 Jan 13;277:275–282. doi: 10.1016/j.expneurol.2016.01.008

Figure 5. Direct delivery of GDNF using hMSCs influences inflammation and TSC survival in SOD1G93A rats.

Figure 5

hMSCs genetically modified to secrete GDNF, were transplanted in the hindlimb muscle of pre-symptomatic SOD1G93A rats. (A) Representative images of CD11b in symptomatic muscle injected with vehicle control or GDNF-secreting hMSCs. (B) Relative intensity of CD11b-positive signals in the muscle sections. TSCs labeled with S100β (C), and GFRα1 (D) at the pre-synaptic area of neuromuscular connections. (E) Direct delivery of GDNF using hMSCs significantly increased TSCs. Scale bars: 100 μm in A; 10 μm in D. *: P<0.05 vs. Control.