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. Author manuscript; available in PMC: 2016 Feb 22.
Published in final edited form as: J Alzheimers Dis. 2009;18(1):211–230. doi: 10.3233/JAD-2009-1138

Fig. 5. Lifespan profile of BACE1 secretase activity in the mouse and primate brain.

Fig. 5

Protein from cortical tissue of mouse and Cynomolgus primate was isolated and BACE1 activity measured using the BACE1 activity assay kit (R&D Systems, Inc., MN). The y–axis reports raw intensity numbers from fluorescence spectrophotometry. A) BACE1 activity in mice at six time points. B) BACE1 activity in monkeys at three time points. Each data point in the curve is the mean + SEM (n=3 animals). “*” denotes significant difference for SP1 or AβPP mRNA time point when compared to PND 365 for mouse or 12 years age for monkey.