Table 1.

Hormonal evaluation of pNET. pNET medium was collected after 48 h incubation for GHRH and calcitonin measurements. The pituitary cell culture was incubated for 4 h with the pNET-conditioned medium which then was collected for GH measurement

Test	Patient	Control/normal range
Blood
GHRH (ng/l)	1273	<60
Calcitonin (pg/ml)	978	<5
In vitro
Incubation of pNET with medium
pNET-derived GHRH release (ng/l)	57 404	Undetected
pNET-derived calcitonin release (pg/ml)	3798	Undetected
Effect of pNET-derived medium on GH release from human pituitary culture
Change in GH release	36% increase	No change in the presence of control medium