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. Author manuscript; available in PMC: 2017 Feb 2.
Published in final edited form as: Radiat Res. 2016 Feb 2;185(2):169–181. doi: 10.1667/RR14285.1

FIG. 1.

FIG. 1

The hypoxic microenvironment increases CSC radioresistance. Panels A and B: CSC maintained in normoxia (20% O2) and hypoxia (5% O2) were exposed to increasing doses of radiation, as indicated. Cells were further maintained for 14 days after the media was replaced. Colonies (>50 cells) were stained and counted (see Materials and Methods). Data represent means ± SD (n = 3). Significant change in the surviving fraction of the CSC population maintained in hypoxic and normoxic conditions after 5 Gy irradiation (recorded as *P < 0.01).