Table 2.

Association of PON1_-108 genotype^a with DNA methylation in blood in newborns and 9-year olds

				Newborns			9-Year Olds
CpG Site	CpG site id	Relation to island	N	Beta (95% CI)	P	N	Beta (95% CI)	P
1	cg22798737	Open sea	271	−0.06(−0.14,0.03)	0.20	218	0.00(−0.07,0.06)	0.97
2	cg01879893	Open sea	271	−0.04(−0.12,0.03)	0.23	218	0.00(−0.07,0.07)	0.90
3	cg09416203	Open sea	271	−0.08(−0.15, −0.01)	0.03	218	−0.03(−0.11,0.05)	0.42
4	cg24062571	N_Shelf	271	−0.05(−0.12,0.02)	0.18	218	−0.01(−0.07,0.06)	0.86
5	cg07404485	N_Shore	271	0.32(0.24,0.39)	8.28E-15	218	0.51(0.45,0.58)	6.58E-37
6	cg05342682	N_Shore	271	0.32(0.25,0.40)	5.00E-15	218	0.52(0.45,0.58)	5.54E-35
7	cg04155289	Island	271	0.33(0.24,0.42)	1.34E-11	218	0.59(0.51,0.67)	6.28E-33
8	cg19678392	Island	271	0.63(0.54,0.73)	4.13E-30	218	0.92(0.82,1.02)	5.73E-45
9	cg21856205	Island	271	0.26(0.22,0.30)	2.73E-30	218	0.35(0.31,0.39)	4.71E-46
10	cg17330251	Island	271	0.63(0.52,0.74)	2.15E-25	218	0.95(0.85,1.04)	4.56E-48
11	cg01874867	S_Shore	271	0.59(0.49,0.69)	8.59E-25	218	0.92(0.82,1.01)	7.55E-50
12	cg20119798	S_Shore	271	0.38(0.30,0.47)	2.14E-16	218	0.69(0.61,0.77)	3.77E-40
13	cg04871131	S_Shore	271	0.26(0.17,0.34)	8.04E-09	218	0.52(0.44,0.61)	1.55E-24
14	cg23055772	S_Shore	271	−0.01(−0.06,0.05)	0.76	218	0.00(−0.05,0.05)	0.86
15	cg07809369	S_Shore	271	0.05(−0.04,0.13)	0.31	218	0.20(0.12,0.28)	1.29E-06
16	cg15887283	S_Shore	271	−0.06(−0.14,0.03)	0.18	218	−0.02(−0.09,0.05)	0.64

CI, confidence interval.

^a PON1_-108 genotype was coded as 0, 1, and 2 T alleles for CC, CT, and TT children, respectively.