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Survival analysis of AML cases categorized by RUNX3 methylation status. (A) Non-inv(16) AMLs have poor overall survival that does not differ between RUNX3 hypermethylated (solid line) and unmethylated groups (dotted line). (B) Relapse-free survival was significantly longer in unmethylated RUNX3 non-inv(16) cases. (C and D) Trend toward longer overall and relapse-free survival in unmethylated RUNX3 inv(16) AML cases but not statistically significant.
