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. 2016 Feb 15;30(4):447–459. doi: 10.1101/gad.272153.115

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© 2016 Elmore et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — Model for limitation of Cmr nuclease activity to invader DNA. (A) The Cmr complex DNA nuclease is activated and tethered by the nascent target RNA. The transcribed invader RNA containing the crRNA target sequence (orange) and rPAM (red) is recognized by the Cmr complex containing the crRNA with the guide sequence (gray). The activated nuclease is tethered to and cleaves the invader DNA. (B) As the length of the tether increases, the Cmr complex DNA nuclease is deactivated by cleavage of the target RNA.